What is PDRN skincare? The K-beauty trend that promises glass skin
Polynucleotides are one of the fastest growing aesthetic treatments of the past half-decade. In fact, according to one report by Two Face Aesthetics, Google Trends has shown a significant increase in searches for the procedure – 1,566% more, to be exact.
Perfectly in line with our continued evolving taste in more natural-looking injectables that boost longevity and skin wellbeing overall (rather than ‘obvious’ enhancements), polynucleotides help with hydration, collagen production, skin repair, and regeneration.
However, as with all injectables, there is a cost associated with these procedures – and they’re not exactly affordable. Considering most patients will require two to three appointments to really reap the rewards from their treatment, the financial implications of signing up to these can often deter beauty fans.
Luckily, you’ve got alternatives if you want to achieve that revered polynucleotides glow. While topical products won’t offer the depth and longevity that injectables can, they are a great place to start, and the rise of PDRN-powered products are proof of this.
Beloved by derms and doctors (and rumoured to be used by celebrities like Kim Kardashian and Jennifer Aniston), this is an ingredient you should take note of if you’re looking to unveil stronger, healthier skin.
What is PDRN and how can it benefit your skin?
PDRN is an acronym for PolyDeoxyRiboNucleotide, which is a DNA fragment typically derived from fish like salmon or trout. It is a form of polynucleotide with a slightly lower molecular weight, and can be used in aesthetic treatments or at-home skincare routines.
“When injected, PDRN stimulates fibroblasts, cells responsible for producing collagen and repairing damaged skin. In skincare it’s gaining popularity for its restorative and soothing effects, even when used in topical form,” explains Dr Christine Hall, Aesthetic Doctor and Korean skincare expert at Taktouk Clinic.
PDRN – which first gained traction and popularity in South Korea – has been hailed for its skin healing and regenerative properties, both in a medical and cosmetic sense.
When used topically as part of your skincare routine, it can do everything from boosting hydration, increasing collagen production (hence, aiding in anti-ageing), brightening, and improving skin tone, texture and resilience.
“It hydrates the skin, reduces inflammation and helps to support the skin’s natural repair processes,” notes Dr Hall. “These effects are particularly valuable for compromised or post-procedure skin where it can aid recovery and improve skin texture and comfort.”
James Devaney//Getty Images
Can PDRN replace polynucleotides treatments?
In short, yes and no. In terms of skin penetration, there’s no contest between injectable absorption of PDRN and topical application, the experts agree. “It won’t penetrate as deeply or work as dramatically as injectables,” says Cosmetic Doctor Dr Raquel Amado.
“Results may take longer and be less pronounced,” when using PDRN skincare, she adds. This is largely due to PDRN’s larger molecular size, meaning it cannot penetrate as deeply when applied at the surface versus injected beneath. However, she says, “while it won’t deliver the same depth of regeneration since it cannot penetrate the skin barrier effectively, it can still offer visible improvements in hydration, calmness and surface repair.”
It therefore “provides a more affordable and non-invasive alternative to injectable treatments,” and is “a worthwhile addition to a skincare routine, particularly for maintaining skin health and supporting recovery.”
In addition, PDRN topical application can be a great complementary skincare addition for those attending Polynucleotides appointments. Together, they can offer the best possible results.
“Polynucleotides (PNs) are longer DNA chains with deep regenerative abilities. PDRN, being a shorter fragment, acts more rapidly and is easier to absorb topically,” explains Dr Amado.
“When combined, PDRN can be used between injectable PN treatments to maintain and enhance effects. It can prep the skin before procedures, improving skin condition and tolerance, and works synergistically to amplify wound healing, hydration, and collagen synthesis.”
Who can use PDRN skincare?
Luckily, PDRN is well-tolerated by most, and because it’s an ingredient that’s used to hydrate and heal skin, it’s relatively gentle. In saying that, there are some who may wish to steer clear of it. For example, due to the fact it is derived from fish like salmon, anyone with a fish allergy will find it not to be suitable. In addition, says Dr Hall, “it may also not be appropriate for vegans, vegetarians, or those with religious or ethical concerns regarding animal-derived ingredients.”
Dr Amado adds that those who are pregnant or breastfeeding, immunocompromised or experiencing severe skin conditions, should always consult a doctor before trying the ingredient.
How to use PDRN in your routine
As PDRN is all about hydration, rejuvenation and healing, it’s best to try a leave-on product like a serum or cream – note too that serums are often the greatest vehicles for delivery as they can penetrate more deeply into the skin due to their make-up of smaller molecule sizes. Korean skincare brands are known for their inclusion of PDRN, making them a great place to start.
Banobagi PDRN Repair Real Balm
Credit: Banobagi
Focused on reparative care for dry, delicate skin, this balm is like a soothing salve for the face.
Medicube Medicube PDRN Pink Peptide Serum
Credit: Medicube
A popular formula that’s both lightweight and non-sticky, Medicube’s serum delivers bouncier skin with better elasticity.
Anua PDRN Hyaluronic Acid Capsule 100 Serum
Credit: Anua
For just £20, you can get in on the salmon sperm trend with this serum, which you can pick up at Boots.
Genabelle PDRN Rejuvenating Cream
Credit: Genabelle
Want something even more hydrating? Genabelle’s cream is suitable for all skin types, and helps with hydration and skin cell regeneration.
